milan米兰体育 假设的个性化风险信息对苏格兰接受结直肠癌筛查结肠镜检查 (PERICCS) 的知情选择和意愿的影响 - 一项随机对照试验

引用

Digby J、O’Carroll RE、Chambers JA 和 Steele RJC (2020) 假设的个性化风险信息对苏格兰接受结直肠癌筛查结肠镜检查 (PERICCS) 的知情选择和意向的影响 - 一项随机对照试验。BMC 医学，18，艺术。编号：285。https://doi.org/10.1186/s12916-020-01750-3

摘要
Background There is currently no existing evidence on the effects of personalised risk information on uptake of colonoscopy following first line screening for colorectal cancer. This study aimed to measure the impact of providing risk information based on faecal haemoglobin concentration to allow a fully informed choice around whether or not to undergo colonoscopy. Methods Two thousand seven hundred sixty-seven participants from the Scottish Bowel Screening Programme (SBoSP) database, who had not recently been invited for screening, were randomised to receive one of three types of hypothetical risk information materials: (1) numerical risk information (risk categories of one in 40, one in 1600 and one in 3500), (2) categorical risk information (highest, moderate and lowest risk), or (3) positive screening result letter (control group). The primary outcome was the impact of the risk materials on intention to undergo colonoscopy, to allow comparison with the current colonoscopy uptake of 77% for those with a positive screening result in the SBoSP. Secondary outcomes were knowledge, attitudes and emotional responses to the materials. Results Four hundred thirty-four (15.7%) agreed to participate with 100 from the numerical risk group (69.0%), 104 from the categorical risk group (72.2%) and 104 from the control group (71.7%) returning completed materials. Intention to undergo colonoscopy was highest in the highest risk groups for the numerical and categorical study arms (96.8% and 95.3%, respectively), but even in the lowest risk groups was > 50% (58.1% and 60.7%, respectively). Adequate knowledge of colorectal screening and the risks and benefits of colonoscopy was found in ≥ 98% of participants in all three arms. All participants reported that they found the information easy-to-understand. 19.1%, 24.0% and 29.6% of those in the numerical, categorical and control group, respectively, reported that they found the information distressing (p > 0.05）。 结论 将风险类别应用于现有的 SBoSP 数据表明，如果向所有参与者提供进行结肠镜检查的知情选择，则超过三分之二的参与者将打算进行测试。相当于筛查结肠镜检查的数量从大约增加到每年 14,000 至 400,000 例，这将对结肠镜检查服务提出难以控制的需求，而且检测到的癌症和癌前病变的比例非常小。然而，对这些材料的反应非常积极，这表明向最低和中等风险群体提供风险信息以及目前不建议进行结肠镜检查的建议可能是一种选择。未来的研究需要检查实际的吸收情况。

关键字
知情选择；个性化风险；粪便免疫化学检测；结直肠癌筛查

期刊
BMC 医学：第 18 卷

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