米兰体育app下载 患有 1 型糖尿病的儿童和青少年早餐后的血糖波动和餐后高血糖

引用

Johnson J、Franklin VL、Shepherd A、Chau G、Keen K、Lennon S、Leveridge M、Maclean K、Nicol J、Phillipson V、Roach S、Swart A 和 Galloway SDR (2025) 1 型糖尿病儿童和青少年早餐后血糖变异和餐后高血糖。斯卡拉穆扎 A（编辑）小儿糖尿病，2025 年。https://doi.org/10.1155/pedi/5545726

摘要
目的：本研究旨在描述患有 1 型糖尿病 (T1D) 的儿童和青少年 (CYP) 的血糖变异性 (GV) 并探讨餐后血糖及其与早餐后食物成分的关系。 方法：这是一项使用连续血糖监测 (CGM) 对 1-17 岁 CYP 进行的观察性研究。收集回顾性 CGM 数据以评估 GV，并收集有关早餐和餐后 4 小时的问卷调查，持续 7 天。统计分析包括学生 t 检验和线性混合模型。 结果：共招募了 96 名 CYP，89 名分享了他们的 CGM 数据（平均年龄 10.1±3.8 岁）（44.9% 女性），其中 74 名提交了问卷。日间百分比变异系数 (%CV)（平均值：38.1%±±4.3%）显着高于夜间 %CV (36.4±±5.2)（95% 置信区间 [CI] [0.9, 2.5]，Cohen d = 0.5，p 0.001). Continuous subcutaneous insulin infusion (CSII) users had a significantly higher time in range (TIR) (mean: 61.7% ± 11.0%) than those using multiple daily injections (MDIs) (mean: 55.5% ± 15.0%) (95% CI [0.2, 12], Cohen’s d = 0.5, p = 0.04). Data on 387 breakfast meals were analysed. The preprandial glucose was significantly lower for CSII users (mean: 7.4 ± 2.3 mmol/L) compared with MDI users (mean: 9.5 ± 2.9 mmol/L) (95% CI [1.3,3.3], d = 0.9, p 0.001). Preprandial glucose was significantly associated with mean postprandial glucose (R2 = 0.27, p 0.001). Compared with breakfast meals containing a protein food (n = 71), ingested meals containing breakfast cereals only (n = 76) resulted in a significantly higher mean postprandial glucose (p = 0.01), peak excursion (p = 0.03), area under the curve (AUC) (p = 0.03) and time above range (TAR) (p 0.001) and significantly shorter time to peak (p = 0.01) and lower TIR (p = 0.01). Ingested meals containing only breakfast cereals also resulted in significantly higher glucose excursion at 30, (p 0.001), 60 (p 0.001) and 90 min (p = 0.02) compared with breakfast meals containing a protein food. Conclusions: GV is significantly higher in the diurnal period. Managing T1D with CSII and including a protein food in the breakfast meal may reduce postprandial hyperglycaemia after breakfast in CYP with T1D.

关键字
碳水化合物；连续血糖监测；糖尿病；血糖控制；一顿饭;营养;蛋白质

期刊
小儿糖尿病：2025 年卷

• Johnson 等人 2025 年儿童早餐后血糖变异和餐后高血糖以及